| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SCN8A (1350-1440) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SCN8A |
| Gene ID: |
6334 |
| Uniprot ID: |
SCN8A_HUMAN |
| Immunogen Region: |
1350-1440 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1350-1440 of human SCN8A (NP_055006.1). |
| Immunogen Sequence: |
AGKYHYCFNETSEIRFEIED VNNKTECEKLMEGNNTEIRW KNVKINFDNVGAGYLALLQV ATFKGWMDIMYAAVDSRKPD EQPKYEDNIYM |
| Tissue Specificity | Expressed in the hippocampus with increased expression in epileptic tissue compared to normal adjacent tissue (at protein level). Isoform 5: Expressed in non-neuronal tissues, such as monocytes/macrophages. |
| Post Translational Modifications | May be ubiquitinated by NEDD4L.which would promote its endocytosis. Phosphorylation at Ser-1497 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. |
| Function | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Isoform 5: In macrophages and melanoma cells, may participate in the control of podosome and invadopodia formation. |
| Protein Name | Sodium Channel Protein Type 8 Subunit AlphaSodium Channel Protein Type Viii Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.6 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionAxonMainly Localizes To The Axon Initial SegmentIsoform 5: Cytoplasmic VesicleSome Vesicles Are Localized Adjacent To Melanoma Invadopodia And Macrophage PodosomesDoes Not Localize To The Plasma Membrane |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 8 Subunit Alpha antibodyAnti-Sodium Channel Protein Type Viii Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.6 antibodyAnti-SCN8A antibodyAnti-MED antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
