| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:200-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SCN8A |
| Gene ID: |
6334 |
| Uniprot ID: |
SCN8A_HUMAN |
| Immunogen Region: |
1350-1440 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1350-1440 of human SCN8A (NP_055006.1). |
| Immunogen Sequence: |
AGKYHYCFNETSEIRFEIED VNNKTECEKLMEGNNTEIRW KNVKINFDNVGAGYLALLQV ATFKGWMDIMYAAVDSRKPD EQPKYEDNIYM |
| Tissue Specificity | Expressed in the hippocampus with increased expression in epileptic tissue compared to normal adjacent tissue (at protein level). Isoform 5: Expressed in non-neuronal tissues, such as monocytes/macrophages. |
| Post Translational Modifications | May be ubiquitinated by NEDD4L.which would promote its endocytosis. Phosphorylation at Ser-1497 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. |
| Function | Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. Contributes to neuronal excitability by regulating action potential threshold and propagation. Isoform 5: More specifically expressed in non-neuronal cells, could play a role in sodium release from intracellular compartments and participate in the control of podosomes formation and macrophages adhesion and movement. |
| Protein Name | Sodium Channel Protein Type 8 Subunit AlphaSodium Channel Protein Type Viii Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.6 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionAxonMainly Localizes To The Axon Initial SegmentIsoform 5: Cytoplasmic VesiclePodosome |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 8 Subunit Alpha antibodyAnti-Sodium Channel Protein Type Viii Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.6 antibodyAnti-SCN8A antibodyAnti-MED antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
