| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SCN7A (800-850 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
SCN7A |
| Gene ID: |
6332 |
| Uniprot ID: |
SCN7A_HUMAN |
| Immunogen Region: |
800-850 aa |
| Specificity: |
Specific for SCN7A (also known as SCN6A). |
| Immunogen: |
A synthetic peptide from aa region 800-850 of human SCN7A conjugated to blue carrier protein was used as the antigen. |
| Function | Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient. In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body. By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis. |
| Protein Name | Sodium Channel Protein Type 7 Subunit AlphaAtypical Sodium Channel Nav2.1Nax ChannelSodium Channel Protein Type Vii Subunit Alpha |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 7 Subunit Alpha antibodyAnti-Atypical Sodium Channel Nav2.1 antibodyAnti-Nax Channel antibodyAnti-Sodium Channel Protein Type Vii Subunit Alpha antibodyAnti-SCN7A antibodyAnti-SCN6A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
