• Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-SCN2A antibody (Internal) (STJ94329)

SKU:
STJ94329

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Sodium channel protein type 2 subunit alpha (Internal) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SCN2A
Gene ID: 6326
Uniprot ID: SCN2A_HUMAN
Immunogen Region: Internal
Specificity: Na+ CP type II Alpha Polyclonal Antibody detects endogenous levels of Na+ CP type II Alpha protein.
Immunogen: Synthesized peptide derived from the Internal region of human Na+ CP type II Alpha.
Post Translational Modifications May be ubiquitinated by NEDD4L.which would promote its endocytosis. Phosphorylation at Ser-1506 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. Sumoylated at Lys-38. Sumoylation is induced by hypoxia, increases voltage-gated sodium current and mediates the early response to acute hypoxia in neurons. Sumoylated SCN2A is located at the cell membrane.
Function Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory.
Protein Name Sodium Channel Protein Type 2 Subunit Alpha
Hbsc Ii
Sodium Channel Protein Brain Ii Subunit Alpha
Sodium Channel Protein Type Ii Subunit Alpha
Voltage-Gated Sodium Channel Subunit Alpha Nav1.2
Database Links Reactome: R-HSA-445095
Reactome: R-HSA-5576892
Reactome: R-HSA-9717207
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Sodium Channel Protein Type 2 Subunit Alpha antibody
Anti-Hbsc Ii antibody
Anti-Sodium Channel Protein Brain Ii Subunit Alpha antibody
Anti-Sodium Channel Protein Type Ii Subunit Alpha antibody
Anti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.2 antibody
Anti-SCN2A antibody
Anti-NAC2 antibody
Anti-SCN2A1 antibody
Anti-SCN2A2 antibody

Information sourced from Uniprot.org

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