| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sodium Channel Protein Type 10 Subunit Alpha (1727-1956) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SCN10A |
| Gene ID: |
6336 |
| Uniprot ID: |
SCNAA_HUMAN |
| Immunogen Region: |
1727-1956 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1727-1956 of human SCN10A (NP_006505.3). |
| Immunogen Sequence: |
VATEESTEPLSEDDFDMFYE TWEKFDPEATQFITFSALSD FADTLSGPLRIPKPNRNILI QMDLPLVPGDKIHCLDILFA FTKNVLGESGELDSLKANME EKFMATNLSKSSYEPIATTL RWKQEDISATVIQKAYRSYV LHRSMALSNTPCVPRAEEEA ASLPDEGFVAFTANENCVLP DKSETASATSFPPSYESVTR GLSDRVNMRTSSSIQNEDEA TSMELIAPGP |
| Tissue Specificity | Expressed in the dorsal root ganglia and sciatic nerve. |
| Post Translational Modifications | Ubiquitinated by NEDD4L.which promotes its endocytosis. Phosphorylation at Ser-1451 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 816) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4. |
| Function | Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. |
| Protein Name | Sodium Channel Protein Type 10 Subunit AlphaPeripheral Nerve Sodium Channel 3Pn3Hpn3Sodium Channel Protein Type X Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.8 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinIt Can Be Translocated To The Cell Membrane Through Association With S100a10 |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 10 Subunit Alpha antibodyAnti-Peripheral Nerve Sodium Channel 3 antibodyAnti-Pn3 antibodyAnti-Hpn3 antibodyAnti-Sodium Channel Protein Type X Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.8 antibodyAnti-SCN10A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
