| Post Translational Modifications | Phosphorylated by the Src-family protein tyrosine kinases LYN and SRC. Phosphorylation occurs on tyrosine residues upon MHC-II stimulation. Phosphorylation also occurs on tyrosine residues after activation of CLEC7A/DECTIN1 by particulate beta-glucan. Lipopolysaccharide (LPS) induces phosphorylation of Tyr-69, Tyr-107 and Tyr-131 differentially to allow temporal recruitment of effector proteins GRB2, CSK and BLNK. Phosphorylation of Tyr-69 is immediately induced by LPS stimulation and allows GRB2 to bind. Tyr-107 is phosphorylated 5 minutes after LPS stimulation, which then allows CSK to bind, followed by phosphorylation of Tyr-131 10 minutes after LPS induction, which allows BLNK to bind. Phosphorylation at Tyr-107 by LYN occurs after activation of TLR4 by lipopolysaccharide.phosphorylation enhances binding to TLR4. Palmitoylated. |
| Function | Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells. It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation. In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans. It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases. |
| Protein Name | Slp Adapter And Csk-Interacting Membrane ProteinSlp65/Slp76 - Csk-Interacting Membrane Protein |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinLipid-AnchorCytoplasmic VesiclePhagosomeCell ProjectionRuffleFilopodiumTogether With Mhc-IiAssociates With Lipid-Enriched Microdomains Called Tetraspanin-Enriched Microdomains (Tems)Rapidly Translocates Into Immunological Synapse (Is) At Cell-Cell Contacts Between Antigen-Presenting Cells (Apcs) And T-CellsColocalized With Tetraspanins Cd37Cd53And Cd81 At The UropodPresent At Regions Of Cell-Cell Contacts But Also At The Leading Edge Of Migrating CellsLocalizes To Phagosomes In Dendritic Cells After Exposure To Particulate Beta-Glucan |
| Alternative Antibody Names | Anti-Slp Adapter And Csk-Interacting Membrane Protein antibodyAnti-Slp65/Slp76 - Csk-Interacting Membrane Protein antibodyAnti-SCIMP antibodyAnti-C17orf87 antibodyAnti-UNQ5783 antibodyAnti-PRO16090 antibody |
Information sourced from Uniprot.org
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