| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SCG3 |
| Gene ID: | 29106 |
| Uniprot ID: | SCG3_HUMAN |
| Immunogen Region: | 199-468 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 199-468 of human SCG3 (NP_037375.2). |
| Immunogen Sequence: | KLISKEANNYEEDPNKPTSW TENQAGKIPEKVTPMAAIQD GLAKGENDETVSNTLTLTNG LERRTKTYSEDNFEELQYFP NFYALLKSIDSEKEAKEKET LITIMKTLIDFVKMMVKYGT ISPEEGVSYLENLDEMIALQ TKNKLEKNATDNISKLFPAP SEKSHEETDSTKEEAAKMEK EYGSLKDSTKDDNSNPGGKT DEPKGKTEAYLEAIRKNIEW LKKHDKKGNKEDYDLSKMR |
| Tissue Specificity | Detected in urine (at protein level). Expressed in brain, heart, kidney, liver and skeletal muscle. |
| Post Translational Modifications | O-glycosylated. |
| Function | Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway. |
| Protein Name | Secretogranin-3Secretogranin IiiSgiii |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSecretory Vesicle MembranePeripheral Membrane ProteinSecretedAssociated With The Secretory Granule Membrane Through Direct Binding To Cholesterol-Enriched Lipid Rafts |
| Alternative Antibody Names | Anti-Secretogranin-3 antibodyAnti-Secretogranin Iii antibodyAnti-Sgiii antibodyAnti-SCG3 antibodyAnti-UNQ2502 antibodyAnti-PRO5990 antibody |
Information sourced from Uniprot.org
