Anti-SASH1 antibody (1-300) (STJ117442)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SASH1 (1-300) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SASH1 |
| Gene ID | 23328 |
| Uniprot ID | SASH1_HUMAN |
| Immunogen Region | 1-300 |
| Immunogen Sequence | MEDAGAAGPGPEPEPEPEPE PEPAPEPEPEPKPGAGTSEA FSRLWTDVMGILDGSLGNID DLAQQYADYYNTCFSDVCER MEELRKRRVSQDLEVEKPDA SPTSLQLRSQIEESLGFCSA VSTPEVERKNPLHKSNSEDS SVGKGDWKKKNKYFWQNFRK NQKGIMRQTSKGEDVGYVAS EITMSDEERIQLMMMVKEKM ITIEEALARLKEYEAQHRQS AALDPADWPDGSYPTFDGS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SASH1 (NP_056093.3). |
Additional Info
| Tissue Specificity | Expressed ubiquitously, with highest levels in lung, placenta, spleen and thymus. Down-regulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues. Expressed in the epidermis, epidermal keratinocytes, dermal fibroblasts and melanocytes. |
| Function | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis. |
| Protein Name | Sam And Sh3 Domain-Containing Protein 1Proline-Glutamate Repeat-Containing Protein |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Sam And Sh3 Domain-Containing Protein 1 antibodyAnti-Proline-Glutamate Repeat-Containing Protein antibodyAnti-SASH1 antibodyAnti-KIAA0790 antibodyAnti-PEPE1 antibody |
Information sourced from Uniprot.org