| Host: | Rabbit |
| Applications: | WB/IHC-P/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SART1 |
| Gene ID: | 9092 |
| Uniprot ID: | SNUT1_HUMAN |
| Immunogen Region: | 1-255 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human SART1 (NP_005137.1). |
| Immunogen Sequence: | MGSSKKHRGEKEAAGTTAAA GTGGATEQPPRHREHKKHKH RSGGSGGSGGERRKRSRERG GERGSGRRGAEAEARSSTHG RERSQAEPSERRVKREKRDD GYEAAASSKTSSGDASSLSI EETNKLRAKLGLKPLEVNAI KKEAGTKEEPVTADVINPMA LRQREELREKLAAAKEKRLL NQKLGKIKTLGEDDPWLDDT AAWIERSRQLQKEKDLAEKR AKLLEEMDQEFGVSTLVEE |
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Sumoylated with SUMO2. |
| Function | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. |
| Protein Name | U4/U6.U5 Tri-Snrnp-Associated Protein 1Snu66 HomologHsnu66Squamous Cell Carcinoma Antigen Recognized By T-Cells 1Sart-1Hsart-1U4/U6.U5 Tri-Snrnp-Associated 110 Kda ProteinAllergen Hom S 1 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusFound In The Nucleus Of Mitogen-Activated Peripheral Blood Mononuclear Cells (Pbmcs)Tumor CellsOr Normal Cell LinesBut Not In Normal Tissues Except Testis And Fetal Liver Or In Unstimulated PbmcsSuggesting Preferential Expression In Proliferating Cells |
| Alternative Antibody Names | Anti-U4/U6.U5 Tri-Snrnp-Associated Protein 1 antibodyAnti-Snu66 Homolog antibodyAnti-Hsnu66 antibodyAnti-Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 antibodyAnti-Sart-1 antibodyAnti-Hsart-1 antibodyAnti-U4/U6.U5 Tri-Snrnp-Associated 110 Kda Protein antibodyAnti-Allergen Hom S 1 antibodyAnti-SART1 antibody |
Information sourced from Uniprot.org