Function | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. |
Protein Name | Sap Domain-Containing RibonucleoproteinCytokine-Induced Protein Of 29 KdaNuclear Protein Hcc-1Proliferation-Associated Cytokine-Inducible Protein Cip29 |
Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72187Reactome: R-HSA-73856 |
Cellular Localisation | NucleusNucleus Speckle |
Alternative Antibody Names | Anti-Sap Domain-Containing Ribonucleoprotein antibodyAnti-Cytokine-Induced Protein Of 29 Kda antibodyAnti-Nuclear Protein Hcc-1 antibodyAnti-Proliferation-Associated Cytokine-Inducible Protein Cip29 antibodyAnti-SARNP antibodyAnti-HCC1 antibodyAnti-HSPC316 antibody |
Information sourced from Uniprot.org