| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SAP30L (C-Term) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS + 0.02% NaN3 |
| Purification: |
Antigen Affinity Purified |
| Dilution Range: |
WB 1:500-1:1000IHCICCIP |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SAP30L |
| Gene ID: |
79685 |
| Uniprot ID: |
SP30L_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
Reacts with the C-terminal region of human SAP30L. Detects wild-type transfected hSAP30L or GST-hSAP30L fusion protein as well as endogenous hSAP30L in human cell lines (e.g., HEK293 and MCF-7 cells). Detects wild-type transfected hSAP30L or GST-hSAP |
| Immunogen: |
Synthetic peptide corresponding to amino acids from the C-terminal region of human SAP30L. |
| Function | Isoform 1: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import. Isoform 2: Functions as transcription repressor.isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. Isoform 3: Functions as transcription repressor.its activity is marginally lower than that of isoform 1. |
| Protein Name | Histone Deacetylase Complex Subunit Sap30lHcv Non-Structural Protein 4a-Transactivated Protein 2Sin3 Corepressor Complex Subunit Sap30lSin3-Associated Protein P30-Like |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427413Reactome: R-HSA-9679191 |
| Cellular Localisation | Isoform 1: NucleusNucleolusIsoform 2: NucleusIsoform 3: Nucleus |
| Alternative Antibody Names | Anti-Histone Deacetylase Complex Subunit Sap30l antibodyAnti-Hcv Non-Structural Protein 4a-Transactivated Protein 2 antibodyAnti-Sin3 Corepressor Complex Subunit Sap30l antibodyAnti-Sin3-Associated Protein P30-Like antibodyAnti-SAP30L antibodyAnti-NS4ATP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
