| Function | Isoform 1: Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import. Isoform 2: Functions as a transcription repressor.isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. Isoform 3: Functions as a transcription repressor.its activity is marginally lower than that of isoform 1. |
| Protein Name | Histone Deacetylase Complex Subunit Sap30lHcv Non-Structural Protein 4a-Transactivated Protein 2Sin3 Corepressor Complex Subunit Sap30lSin3-Associated Protein P30-Like |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427413Reactome: R-HSA-9679191 |
| Cellular Localisation | Isoform 1: NucleusNucleolusIsoform 2: NucleusIsoform 3: Nucleus |
| Alternative Antibody Names | Anti-Histone Deacetylase Complex Subunit Sap30l antibodyAnti-Hcv Non-Structural Protein 4a-Transactivated Protein 2 antibodyAnti-Sin3 Corepressor Complex Subunit Sap30l antibodyAnti-Sin3-Associated Protein P30-Like antibodyAnti-SAP30L antibodyAnti-NS4ATP2 antibody |
Information sourced from Uniprot.org
