| Short Description : | Rabbit polyclonal anti-Sterile alpha motif domain-containing protein 1 (418-468 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SAMD1 |
| Gene ID: | 90378 |
| Uniprot ID: | SAMD1_HUMAN |
| Immunogen: | Synthesized peptide derived from the human SAMD1 at the amino acid range 418-468 |
| Immunogen Region: | 418-468 aa |
| Specificity: | This antibody detects endogenous levels of SAMD1 at Human/Mouse |
| Function | Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor. Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs. Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell. |
| Protein Name | Sterile Alpha Motif Domain-Containing Protein 1Sam Domain-Containing Protein 1Atherin |
| Database Links | |
| Cellular Localisation | NucleusChromosomeSecretedIn Atherosclerotic LesionsIt Is Found In The Extracellular Compartment And In Foam Cells Cytoplasm |
| Alternative Antibody Names | Anti-Sterile Alpha Motif Domain-Containing Protein 1 antibodyAnti-Sam Domain-Containing Protein 1 antibodyAnti-Atherin antibodyAnti-SAMD1 antibody |
Information sourced from Uniprot.org
