Anti-S100A4 antibody (50-101 aa) [ABT-S100A4] (STJ196865)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenSynthesized peptide derived from the human S100A4 at the amino acid range 50-101
General Information
| Short Description | Mouse monoclonal anti-Protein S100-A4 (50-101 aa) for use in IHC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | ABT-S100A4 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range | IHC-P 1:100-500IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | S100A4 |
| Gene ID | 6275 |
| Uniprot ID | S10A4_HUMAN |
| Immunogen | Synthesized peptide derived from the human S100A4 at the amino acid range 50-101 |
| Immunogen Region | 50-101 aa |
| Specificity | This antibody detects endogenous levels of human S100A4. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section |
Additional Info
| Function | Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9. Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis. Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels. Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes. In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors. |
| Protein Name | Protein S100-A4CalvasculinMetastasinPlacental Calcium-Binding ProteinProtein Mts1S100 Calcium-Binding Protein A4 |
| Database Links | |
| Cellular Localisation | SecretedNucleusCytoplasm |
| Alternative Antibody Names | Anti-Protein S100-A4 antibodyAnti-Calvasculin antibodyAnti-Metastasin antibodyAnti-Placental Calcium-Binding Protein antibodyAnti-Protein Mts1 antibodyAnti-S100 Calcium-Binding Protein A4 antibodyAnti-S100A4 antibodyAnti-CAPL antibodyAnti-MTS1 antibody |
Information sourced from Uniprot.org