| Host: |
Rabbit |
| Applications: |
WB/IHC-P/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IHC-P:1:100-1:500IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
RYR2 |
| Gene ID: |
6262 |
| Uniprot ID: |
RYR2_HUMAN |
| Immunogen Region: |
1411-1510 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 1411-1510 of human RYR2 (NP_001026.2). |
| Immunogen Sequence: |
ADDRDDYDFLMQTSTYYYSV RIFPGQEPANVWVGWITSDF HQYDTGFDLDRVRTVTVTLG DEKGKVHESIKRSNCYMVCA GESMSPGQGRNNNGLEIGCV |
| Tissue Specificity | Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta. |
| Post Translational Modifications | Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2808 and Ser-2814 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca(2+) levels. Phosphorylation at Ser-2031 by PKA enhances the response to lumenal calcium. |
| Function | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. |
| Protein Name | Ryanodine Receptor 2Ryr-2Ryr2Hryr-2Cardiac Muscle Ryanodine ReceptorCardiac Muscle Ryanodine Receptor-Calcium Release ChannelType 2 Ryanodine Receptor |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-5578775 |
| Cellular Localisation | Sarcoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ryanodine Receptor 2 antibodyAnti-Ryr-2 antibodyAnti-Ryr2 antibodyAnti-Hryr-2 antibodyAnti-Cardiac Muscle Ryanodine Receptor antibodyAnti-Cardiac Muscle Ryanodine Receptor-Calcium Release Channel antibodyAnti-Type 2 Ryanodine Receptor antibodyAnti-RYR2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
