| Function | Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination. |
| Protein Name | Rwd Domain-Containing Protein 3Rwd Domain-Containing Sumoylation EnhancerRsume |
| Database Links | Reactome: R-HSA-3065678 |
| Cellular Localisation | NucleusCytoplasmColocalizes With Ubc9/Ube2i In Nuclear Spots |
| Alternative Antibody Names | Anti-Rwd Domain-Containing Protein 3 antibodyAnti-Rwd Domain-Containing Sumoylation Enhancer antibodyAnti-Rsume antibodyAnti-RWDD3 antibodyAnti-RSUME antibody |
Information sourced from Uniprot.org
