| Tissue Specificity | Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary. |
| Function | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12. Acts as a negative regulator of adipogenesis. The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal. |
| Protein Name | Protein Cbfa2t1Cyclin-D-Related ProteinEight Twenty One ProteinProtein EtoProtein Mtg8Zinc Finger Mynd Domain-Containing Protein 2 |
| Database Links | |
| Cellular Localisation | NucleusColocalizes With Atn1 In Discrete Nuclear Dots |
| Alternative Antibody Names | Anti-Protein Cbfa2t1 antibodyAnti-Cyclin-D-Related Protein antibodyAnti-Eight Twenty One Protein antibodyAnti-Protein Eto antibodyAnti-Protein Mtg8 antibodyAnti-Zinc Finger Mynd Domain-Containing Protein 2 antibodyAnti-RUNX1T1 antibodyAnti-AML1T1 antibodyAnti-CBFA2T1 antibodyAnti-CDR antibodyAnti-ETO antibodyAnti-MTG8 antibodyAnti-ZMYND2 antibody |
Information sourced from Uniprot.org
