| Function | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. |
| Protein Name | Reticulon-3Homolog Of Asy ProteinHapNeuroendocrine-Specific Protein-Like 2Nsp-Like Protein 2Neuroendocrine-Specific Protein-Like IiNsp-Like Protein IiNsplii |
| Database Links | Reactome: R-HSA-8849932 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Reticulon-3 antibodyAnti-Homolog Of Asy Protein antibodyAnti-Hap antibodyAnti-Neuroendocrine-Specific Protein-Like 2 antibodyAnti-Nsp-Like Protein 2 antibodyAnti-Neuroendocrine-Specific Protein-Like Ii antibodyAnti-Nsp-Like Protein Ii antibodyAnti-Nsplii antibodyAnti-RTN3 antibodyAnti-ASYIP antibodyAnti-NSPL2 antibody |
Information sourced from Uniprot.org
