Anti-RSF1 antibody (350-430 aa) (STJ191310)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 350-430
General Information
| Short Description | Rabbit polyclonal anti-Remodeling and spacing factor 1 (350-430 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RSF1 |
| Gene ID | 51773 |
| Uniprot ID | RSF1_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 350-430 |
| Immunogen Region | 350-430 aa |
| Specificity | RSF1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylated. |
| Function | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex. Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively. The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex. The complexes do not have the ability to slide mononucleosomes to the center of a DNA template. Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain. |
| Protein Name | Remodeling And Spacing Factor 1Rsf-1Hbv Px-Associated Protein 8Hepatitis B Virus X-Associated ProteinP325 Subunit Of Rsf Chromatin-Remodeling Complex |
| Database Links | Reactome: R-HSA-606279 |
| Cellular Localisation | NucleusLocalization Is Diffuse During MitosisCo-Localizes With Smarca5 In The Nucleus |
| Alternative Antibody Names | Anti-Remodeling And Spacing Factor 1 antibodyAnti-Rsf-1 antibodyAnti-Hbv Px-Associated Protein 8 antibodyAnti-Hepatitis B Virus X-Associated Protein antibodyAnti-P325 Subunit Of Rsf Chromatin-Remodeling Complex antibodyAnti-RSF1 antibodyAnti-HBXAP antibodyAnti-XAP8 antibody |
Information sourced from Uniprot.org