| Post Translational Modifications | Phosphorylated. |
| Function | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex. Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively. The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex. The complexes do not have the ability to slide mononucleosomes to the center of a DNA template. Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain. |
| Protein Name | Remodeling And Spacing Factor 1Rsf-1Hbv Px-Associated Protein 8Hepatitis B Virus X-Associated ProteinP325 Subunit Of Rsf Chromatin-Remodeling Complex |
| Database Links | Reactome: R-HSA-606279 |
| Cellular Localisation | NucleusLocalization Is Diffuse During MitosisCo-Localizes With Smarca5 In The Nucleus |
| Alternative Antibody Names | Anti-Remodeling And Spacing Factor 1 antibodyAnti-Rsf-1 antibodyAnti-Hbv Px-Associated Protein 8 antibodyAnti-Hepatitis B Virus X-Associated Protein antibodyAnti-P325 Subunit Of Rsf Chromatin-Remodeling Complex antibodyAnti-RSF1 antibodyAnti-HBXAP antibodyAnti-XAP8 antibody |
Information sourced from Uniprot.org
