| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Remodeling and spacing factor 1 (350-430 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RSF1 |
| Gene ID: |
51773 |
| Uniprot ID: |
RSF1_HUMAN |
| Immunogen Region: |
350-430 aa |
| Specificity: |
RSF1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 350-430 |
| Post Translational Modifications | Phosphorylated. |
| Function | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex. Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively. The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex. The complexes do not have the ability to slide mononucleosomes to the center of a DNA template. Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain. |
| Protein Name | Remodeling And Spacing Factor 1Rsf-1Hbv Px-Associated Protein 8Hepatitis B Virus X-Associated ProteinP325 Subunit Of Rsf Chromatin-Remodeling Complex |
| Database Links | Reactome: R-HSA-606279 |
| Cellular Localisation | NucleusLocalization Is Diffuse During MitosisCo-Localizes With Smarca5 In The Nucleus |
| Alternative Antibody Names | Anti-Remodeling And Spacing Factor 1 antibodyAnti-Rsf-1 antibodyAnti-Hbv Px-Associated Protein 8 antibodyAnti-Hepatitis B Virus X-Associated Protein antibodyAnti-P325 Subunit Of Rsf Chromatin-Remodeling Complex antibodyAnti-RSF1 antibodyAnti-HBXAP antibodyAnti-XAP8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
