| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specif |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RRM2 |
| Gene ID: | 6241 |
| Uniprot ID: | RIR2_HUMAN |
| Immunogen Region: | 1-389 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-389 of human RRM2 (NP_001025.1). |
| Immunogen Sequence: | MLSLRVPLAPITDPQQLQLS PLKGLSLVDKENTPPALSGT RVLASKTARRIFQEPTEPKT KAAAPGVEDEPLLRENPRRF VIFPIEYHDIWQMYKKAEAS FWTAEEVDLSKDIQHWESLK PEERYFISHVLAFFAASDGI VNENLVERFSQEVQITEARC FYGFQIAMENIHSEMYSLLI DTYIKDPKEREFLFNAIETM PCVKKKADWALRWIGDKEAT YGERVVAFAAVEGIFFSGS |
| Post Translational Modifications | Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling. Phosphorylated on Thr-33 by CDK1 and CDK2.predominantly in G2 and M phase. Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex.leading to its degradation by the proteasome. |
| Function | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. |
| Protein Name | Ribonucleoside-Diphosphate Reductase Subunit M2Ribonucleotide Reductase Small ChainRibonucleotide Reductase Small Subunit |
| Database Links | Reactome: R-HSA-499943Reactome: R-HSA-69205Reactome: R-HSA-8953750 |
| Cellular Localisation | CytoplasmNucleusLocalized To The Cytoplasm In S Phase CellsMay Localize To The Nucleus In G2 Phase Cells |
| Alternative Antibody Names | Anti-Ribonucleoside-Diphosphate Reductase Subunit M2 antibodyAnti-Ribonucleotide Reductase Small Chain antibodyAnti-Ribonucleotide Reductase Small Subunit antibodyAnti-RRM2 antibodyAnti-RR2 antibody |
Information sourced from Uniprot.org