| Host: |
Mouse |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-GTP-binding protein RAD (1-100) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
PTR2260 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1k |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.05% Proclin 300. |
| Purification: |
The antibody was purified using affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RRAD |
| Gene ID: |
6236 |
| Uniprot ID: |
RAD_HUMAN |
| Immunogen Region: |
1-100 |
| Specificity: |
This antibody detects endogenous levels of RRAD at Human |
| Immunogen: |
Synthesized peptide derived from human protein. AA range: 1-100 |
| Tissue Specificity | Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans. |
| Function | May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D. |
| Protein Name | Gtp-Binding Protein RadRad1Ras Associated With Diabetes |
| Database Links | Reactome: R-HSA-9031628 |
| Cellular Localisation | Cell Membrane |
| Alternative Antibody Names | Anti-Gtp-Binding Protein Rad antibodyAnti-Rad1 antibodyAnti-Ras Associated With Diabetes antibodyAnti-RRAD antibodyAnti-RAD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
