| Short Description : | Rabbit polyclonal RPS3A (1-264) antibody for use in WB, IHC-P, IF, ICC, IP and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/IF/ICC/IP/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specif |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RPS3A |
| Gene ID: | 6189 |
| Uniprot ID: | RS3A_HUMAN |
| Immunogen Region: | 1-264 |
| Immunogen Sequence: | MAVGKNKRLTKGGKKGAKKK VVDPFSKKDWYDVKAPAMFN IRNIGKTLVTRTQGTKIASD GLKGRVFEVSLADLQNDEVA FRKFKLITEDVQGKNCLTNF HGMDLTRDKMCSMVKKWQTM IEAHVDVKTTDGYLLRLFCV GFTKKRNNQIRKTSYAQHQQ VRQIRKKMMEIMTREVQTND LKEVVNKLIPDSIGKDIEKA CQSIYPLHDVFVRKVKMLKK PKFELGKLMELHGEGSSSG |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-264 of human RPS3A (NP_000997.1). |
| Post Translational Modifications | ADP-ribosylated at Tyr-155 by PARP1 in presence of HPF1. |
| Function | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. May play a role during erythropoiesis through regulation of transcription factor DDIT3. |
| Protein Name | Small Ribosomal Subunit Protein Es140s Ribosomal Protein S3aV-Fos Transformation Effector ProteinFte-1 |
| Database Links | Reactome: R-HSA-156827Reactome: R-HSA-156902Reactome: R-HSA-1799339Reactome: R-HSA-192823Reactome: R-HSA-2408557Reactome: R-HSA-6791226Reactome: R-HSA-72649Reactome: R-HSA-72689Reactome: R-HSA-72695Reactome: R-HSA-72702Reactome: R-HSA-72706Reactome: R-HSA-72764Reactome: R-HSA-9010553Reactome: R-HSA-9633012Reactome: R-HSA-9735869Reactome: R-HSA-9754678Reactome: R-HSA-975956Reactome: R-HSA-975957 |
| Cellular Localisation | CytoplasmNucleusNucleolusLocalized In Cytoplasmic Mrnp Granules Containing Untranslated Mrnas |
| Alternative Antibody Names | Anti-Small Ribosomal Subunit Protein Es1 antibodyAnti-40s Ribosomal Protein S3a antibodyAnti-V-Fos Transformation Effector Protein antibodyAnti-Fte-1 antibodyAnti-RPS3A antibodyAnti-FTE1 antibodyAnti-MFTL antibody |
Information sourced from Uniprot.org
