| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RPL23A |
| Gene ID: | 6147 |
| Uniprot ID: | RL23A_HUMAN |
| Immunogen Region: | 1-156 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-156 of human RPL23A (NP_000975.2). |
| Immunogen Sequence: | MAPKAKKEAPAPPKAEAKAK ALKAKKAVLKGVHSHKKKKI RTSPTFRRPKTLRLRRQPKY PRKSAPRRNKLDHYAIIKFP LTTESAMKKIEDNNTLVFIV DVKANKHQIKQAVKKLYDID VAKVNTLIRPDGEKKAYVRL APDYDALDVANKIGII |
| Post Translational Modifications | N-terminus is methylated by METTL11A/NTM1. Citrullinated by PADI4. |
| Function | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination. |
| Protein Name | Large Ribosomal Subunit Protein Ul2360s Ribosomal Protein L23a |
| Database Links | Reactome: R-HSA-156827Reactome: R-HSA-156902Reactome: R-HSA-1799339Reactome: R-HSA-192823Reactome: R-HSA-2408557Reactome: R-HSA-6791226Reactome: R-HSA-72689Reactome: R-HSA-72706Reactome: R-HSA-72764Reactome: R-HSA-9010553Reactome: R-HSA-9633012Reactome: R-HSA-975956Reactome: R-HSA-975957 |
| Cellular Localisation | CytoplasmNucleusAlthough Rpl23a Is Functional Within The CytoplasmThe Assembly Of Ribosomal Subunits Occurs In The NucleusRpl23a Nuclear Import Is Mediated By Ipo5/Ranbp5Ipo7/Ranbp7Kpnb1/Importin-Beta Or Tpno1/Trn |
| Alternative Antibody Names | Anti-Large Ribosomal Subunit Protein Ul23 antibodyAnti-60s Ribosomal Protein L23a antibodyAnti-RPL23A antibody |
Information sourced from Uniprot.org