• Western blot of rat cortical lysate showing specific immunolabeling of the ~82 kDa rabphilin 3A.

Anti-RPH3A antibody (C-Term) (STJA0003760)

SKU:
STJA0003760-100

£442.50
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Host: Rabbit
Applications: WB
Reactivity: Rat/Bovine/Canine/Human/Non-Human Primates/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Rabphilin 3A (C-Term) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Rph3a
Gene ID: 171039
Uniprot ID: RP3A_RAT
Immunogen Region: C-Term
Immunogen: Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.
Tissue Specificity Specifically expressed in brain.
Post Translational Modifications Ubiquitinated. Deubiquitinated by CAND1 to prevent its degradation.
Function Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone.
Protein Name Rabphilin-3a
Exophilin-1
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle
Synaptic Vesicle Membrane
Cell Projection
Dendritic Spine
Postsynaptic Cell Membrane
Membrane
Peripheral Membrane Protein
Alternative Antibody Names Anti-Rabphilin-3a antibody
Anti-Exophilin-1 antibody
Anti-Rph3a antibody

Information sourced from Uniprot.org

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