| Short Description : | Rabbit polyclonal anti-Rabphilin 3A (C-Term) for use in WB in Rat, Bovine, Canine, Human, Non-Human Primates and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Rat/Bovine/Canine/Human/Non-Human Primates/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | This antibody was antigen affinity purified from pooled serum. |
| Dilution Range: | WB 1:1000 |
| Formulation: | 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Rph3a |
| Gene ID: | 171039 |
| Uniprot ID: | RP3A_RAT |
| Immunogen: | Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH. |
| Immunogen Region: | C-Term |
| Tissue Specificity | Specifically expressed in brain. |
| Post Translational Modifications | Ubiquitinated. Deubiquitinated by CAND1 to prevent its degradation. |
| Function | Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone. |
| Protein Name | Rabphilin-3aExophilin-1 |
| Database Links | |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneCell ProjectionDendritic SpinePostsynaptic Cell MembraneMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Rabphilin-3a antibodyAnti-Exophilin-1 antibodyAnti-Rph3a antibody |
Information sourced from Uniprot.org
