| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Protein fantom is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RPGRIP1L |
| Gene ID: | 23322 |
| Uniprot ID: | FTM_HUMAN |
| Specificity: | This antibody detects endogenous levels of RPGRIP1L at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human RPGRIP1L |
| Function | Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis. Involved in the organization of apical junctions.the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins. Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2. |
| Protein Name | Protein Fantom Nephrocystin-8 Rpgr-Interacting Protein 1-Like Protein Rpgrip1-Like Protein |
| Database Links | Reactome: R-HSA-5610787 Reactome: R-HSA-5620912 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cilium Basal Body Cilium Axoneme Microtubule Organizing Center Centrosome Cell Junction Tight Junction In Cultured Renal Cells It Localizes Diffusely In The Cytoplasm But As Cells Approach Confluence It Accumulates To Basolateral Tight Junctions Localizes To The Ciliary Transition Zone |
| Alternative Antibody Names | Anti-Protein Fantom antibody Anti-Nephrocystin-8 antibody Anti-Rpgr-Interacting Protein 1-Like Protein antibody Anti-Rpgrip1-Like Protein antibody Anti-RPGRIP1L antibody Anti-FTM antibody Anti-KIAA1005 antibody Anti-NPHP8 antibody |
Information sourced from Uniprot.org