| Short Description : | Mouse monoclonal anti-Inactive tyrosine-protein kinase transmembrane receptor ROR1 (30-406 aa) for use in WB, IF and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ELISA |
| Host: | Mouse |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | 2H6 |
| Isotype: | IgG1 |
| Conjugation: | Unconjugated |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:10000 |
| Formulation: | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ROR1 |
| Gene ID: | 4919 |
| Uniprot ID: | ROR1_HUMAN |
| Immunogen: | Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells |
| Immunogen Region: | 30-406 aa |
| Specificity: | ROR1 Monoclonal Antibody detects endogenous levels of ROR1 protein. |
| Function | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling. |
| Protein Name | Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1Neurotrophic Tyrosine Kinase - Receptor-Related 1 |
| Database Links | Reactome: R-HSA-5140745 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxon |
| Alternative Antibody Names | Anti-Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1 antibodyAnti-Neurotrophic Tyrosine Kinase - Receptor-Related 1 antibodyAnti-ROR1 antibodyAnti-NTRKR1 antibody |
Information sourced from Uniprot.org
