| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RNH1 |
| Gene ID: | 6050 |
| Uniprot ID: | RINI_HUMAN |
| Immunogen Region: | 202-461 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 202-461 of human RNH1 (NP_002930.2). |
| Immunogen Sequence: | EALKLESCGVTSDNCRDLCG IVASKASLRELALGSNKLGD VGMAELCPGLLHPSSRLRTL WIWECGITAKGCGDLCRVLR AKESLKELSLAGNELGDEGA RLLCETLLEPGCQLESLWVK SCSFTAACCSHFSSVLAQNR FLLELQISNNRLEDAGVREL CQGLGQPGSVLRVLWLADCD VSDSSCSSLAATLLANHSLR ELDLSNNCLGDAGILQLVES VRQPGCLLEQLVLYDIYWS |
| Post Translational Modifications | The N-terminus is blocked. At least 30 of the 32 cysteine residues are in the reduced form. |
| Function | Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG). May play a role in redox homeostasis. Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress. Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus. |
| Protein Name | Ribonuclease InhibitorPlacental Ribonuclease InhibitorPlacental Rnase InhibitorRibonuclease/Angiogenin Inhibitor 1Rai |
| Cellular Localisation | CytoplasmNucleusLocalizes In The Cytoplasm In Absence Of StressTranslocates To The Nucleus In Response To Stress |
| Alternative Antibody Names | Anti-Ribonuclease Inhibitor antibodyAnti-Placental Ribonuclease Inhibitor antibodyAnti-Placental Rnase Inhibitor antibodyAnti-Ribonuclease/Angiogenin Inhibitor 1 antibodyAnti-Rai antibodyAnti-RNH1 antibodyAnti-PRI antibodyAnti-RNH antibody |
Information sourced from Uniprot.org