| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RNF5 (1-120) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RNF5 |
| Gene ID: |
6048 |
| Uniprot ID: |
RNF5_HUMAN |
| Immunogen Region: |
1-120 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human RNF5 (NP_008844.1). |
| Immunogen Sequence: |
MAAAEEEDGGPEGPNRERGG AGATFECNICLETAREAVVS VCGHLYCWPCLHQWLETRPE RQECPVCKAGISREKVVPLY GRGSQKPQDPRLKTPPRPQG QRPAPESRGGFQPFGDTGGF |
| Tissue Specificity | Widely expressed. |
| Function | Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin. Catalyzes ubiquitination of Salmonella type III secreted protein sopA. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD.the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation.the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses. Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf5Ring Finger Protein 5Ram1 HomologHsrma1 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-5678895Reactome: R-HSA-901032 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMitochondrion MembraneEndoplasmic Reticulum MembranePredominantly Located In The Plasma MembraneWith Some Localization Occurring Within Cytoplasmic Organelles |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf5 antibodyAnti-Ring Finger Protein 5 antibodyAnti-Ram1 Homolog antibodyAnti-Hsrma1 antibodyAnti-RNF5 antibodyAnti-G16 antibodyAnti-NG2 antibodyAnti-RMA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
