| Tissue Specificity | Widely expressed. |
| Function | Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin. Catalyzes ubiquitination of Salmonella type III secreted protein sopA. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD.the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation.the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses. Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf5Ring Finger Protein 5Ram1 HomologHsrma1 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-5678895Reactome: R-HSA-901032 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMitochondrion MembraneEndoplasmic Reticulum MembranePredominantly Located In The Plasma MembraneWith Some Localization Occurring Within Cytoplasmic Organelles |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf5 antibodyAnti-Ring Finger Protein 5 antibodyAnti-Ram1 Homolog antibodyAnti-Hsrma1 antibodyAnti-RNF5 antibodyAnti-G16 antibodyAnti-NG2 antibodyAnti-RMA1 antibody |
Information sourced from Uniprot.org
