| Host: | Rabbit |
| Applications: | WB/ELISA/IHC |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-E3 ubiquitin ligase RNF157 (588-638 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RNF157 |
| Gene ID: | 114804 |
| Uniprot ID: | RN157_HUMAN |
| Immunogen Region: | 588-638 aa |
| Specificity: | This antibody detects endogenous levels of RN157 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human RN157 at the amino acid range 588-638 |
| Function | E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons. Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical. May act as a scaffold molecule to regulate this process. Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle. |
| Protein Name | E3 Ubiquitin Ligase Rnf157Ring Finger Protein 157Ring-Type E3 Ubiquitin Transferase Rnf157 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin Ligase Rnf157 antibodyAnti-Ring Finger Protein 157 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf157 antibodyAnti-RNF157 antibodyAnti-KIAA1917 antibody |
Information sourced from Uniprot.org