Anti-RNF157 antibody (588-638 aa) (STJ194766)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human RN157 at the amino acid range 588-638
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin ligase RNF157 (588-638 aa) for use in WB, ELISA and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RNF157 |
| Gene ID | 114804 |
| Uniprot ID | RN157_HUMAN |
| Immunogen | Synthesized peptide derived from the human RN157 at the amino acid range 588-638 |
| Immunogen Region | 588-638 aa |
| Specificity | This antibody detects endogenous levels of RN157 at Human/Mouse |
Additional Info
| Function | E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons. Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical. May act as a scaffold molecule to regulate this process. Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle. |
| Protein Name | E3 Ubiquitin Ligase Rnf157Ring Finger Protein 157Ring-Type E3 Ubiquitin Transferase Rnf157 |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin Ligase Rnf157 antibodyAnti-Ring Finger Protein 157 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf157 antibodyAnti-RNF157 antibodyAnti-KIAA1917 antibody |
Information sourced from Uniprot.org