Anti-RNF152 antibody (150-200) (STJA0006445)

SKU:
STJA0006445
£48.00 - £252.00
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase RNF152 (150-200) is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RNF152
Gene ID: 220441
Uniprot ID: RN152_HUMAN
Immunogen Region: 150-200
Specificity: This antibody detects endogenous levels of human RN152
Immunogen: Synthesized peptide derived from human RN152 AA range: 150-200
Post Translational Modifications Ubiquitinated. Autoubiquitinated in vitro, leading to its degradation by the proteasome (Probable).
Function E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB. Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling. Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed.
Protein Name E3 Ubiquitin-Protein Ligase Rnf152
Ring Finger Protein 152
Ring-Type E3 Ubiquitin Transferase Rnf152
Database Links Reactome: R-HSA-8866654
Cellular Localisation Lysosome Membrane
Single-Pass Membrane Protein
Alternative Antibody Names Anti-E3 Ubiquitin-Protein Ligase Rnf152 antibody
Anti-Ring Finger Protein 152 antibody
Anti-Ring-Type E3 Ubiquitin Transferase Rnf152 antibody
Anti-RNF152 antibody

Information sourced from Uniprot.org

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