| Tissue Specificity | Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4(+) and CD8(+) T-cells, suggesting that it is preferentially confined to T-cells. |
| Post Translational Modifications | Autoubiquitinated, leading to its subsequent proteasomal degradation. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf125Ring Finger Protein 125T-Cell Ring Activation Protein 1Trac-1 |
| Database Links | Reactome: R-HSA-936440 |
| Cellular Localisation | Golgi Apparatus MembraneLipid-AnchorShows A Reticular Staining Pattern Within The Cell And Is Probably Expressed At Other Intracellular Membranes In Addition To The Golgi MembraneNot Detected At The Plasma Membrane |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf125 antibodyAnti-Ring Finger Protein 125 antibodyAnti-T-Cell Ring Activation Protein 1 antibodyAnti-Trac-1 antibodyAnti-RNF125 antibody |
Information sourced from Uniprot.org
