• Western blot analysis of lysates from K562 and HT-29 cells, using RNF125 Antibody. The lane on the right is blocked with the synthesized peptide.

Anti-RNF125 antibody (131-180 aa) (STJ96080)

SKU:
STJ96080

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase RNF125 (131-180 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RNF125
Gene ID: 54941
Uniprot ID: RN125_HUMAN
Immunogen Region: 131-180 aa
Specificity: TRAC-1 Polyclonal Antibody detects endogenous levels of TRAC-1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human RNF125 at the amino acid range 131-180
Post Translational Modifications Autoubiquitinated, leading to its subsequent proteasomal degradation.
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation.
Protein Name E3 Ubiquitin-Protein Ligase Rnf125
Ring Finger Protein 125
T-Cell Ring Activation Protein 1
Trac-1
Database Links Reactome: R-HSA-936440
Cellular Localisation Golgi Apparatus Membrane
Lipid-Anchor
Shows A Reticular Staining Pattern Within The Cell And Is Probably Expressed At Other Intracellular Membranes In Addition To The Golgi Membrane
Not Detected At The Plasma Membrane
Alternative Antibody Names Anti-E3 Ubiquitin-Protein Ligase Rnf125 antibody
Anti-Ring Finger Protein 125 antibody
Anti-T-Cell Ring Activation Protein 1 antibody
Anti-Trac-1 antibody
Anti-RNF125 antibody

Information sourced from Uniprot.org

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