| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RNASEL (472-741) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RNASEL |
| Gene ID: |
6041 |
| Uniprot ID: |
RN5A_HUMAN |
| Immunogen Region: |
472-741 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 472-741 of human RNASEL (NP_066956.1). |
| Immunogen Sequence: |
VQELHLSCGYTHQDLQPQNI LIDSKKAAHLADFDKSIKWA GDPQEVKRDLEDLGRLVLYV VKKGSISFEDLKAQSNEEVV QLSPDEETKDLIHRLFHPGE HVRDCLSDLLGHPFFWTWES RYRTLRNVGNESDIKTRKSE SEILRLLQPGPSEHSKSFDK WTTKINECVMKKMNKFYEKR GNFYQNTVGDLLKFIRNLGE HIDEEKHKKMKLKIGDPSLY FQKTFPDLVIYVYTKLQNT |
| Tissue Specificity | Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes. |
| Function | Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis. Might play a central role in the regulation of mRNA turnover. Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length. |
| Protein Name | 2-5a-Dependent Ribonuclease2-5a-Dependent RnaseRibonuclease 4Ribonuclease LRnase L |
| Database Links | Reactome: R-HSA-8983711Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Antibody Names | Anti-2-5a-Dependent Ribonuclease antibodyAnti-2-5a-Dependent Rnase antibodyAnti-Ribonuclease 4 antibodyAnti-Ribonuclease L antibodyAnti-Rnase L antibodyAnti-RNASEL antibodyAnti-RNS4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
