| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RING1 |
| Gene ID: | 6015 |
| Uniprot ID: | RING1_HUMAN |
| Immunogen Region: | 207-406 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 207-406 of human RING1A A (NP_002922.2). |
| Immunogen Sequence: | GAGGSSVGTGGGGTGGVGGG AGSEDSGDRGGTLGGGTLGP PSPPGAPSPPEPGGEIELVF RPHPLLVEKGEYCQTRYVKT TGNATVDHLSKYLALRIALE RRQQQEAGEPGGPGGGASDT GGPDGCGGEGGGAGGGDGPE EPALPSLEGVSEKQYTIYIA PGGGAFTTLNGSLTLELVNE KFWKVSRPLELCYAPTKDPK |
| Function | Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. |
| Protein Name | E3 Ubiquitin-Protein Ligase Ring1 Polycomb Complex Protein Ring1 Ring Finger Protein 1 Ring-Type E3 Ubiquitin Transferase Ring1 Really Interesting New Gene 1 Protein |
| Database Links | Reactome: R-HSA-2559580 Reactome: R-HSA-3108214 Reactome: R-HSA-3899300 Reactome: R-HSA-4551638 Reactome: R-HSA-4570464 Reactome: R-HSA-4655427 Reactome: R-HSA-8939243 Reactome: R-HSA-8943724 Reactome: R-HSA-8953750 |
| Cellular Localisation | Nucleus Nucleus Speckle |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Ring1 antibody Anti-Polycomb Complex Protein Ring1 antibody Anti-Ring Finger Protein 1 antibody Anti-Ring-Type E3 Ubiquitin Transferase Ring1 antibody Anti-Really Interesting New Gene 1 Protein antibody Anti-RING1 antibody Anti-RING1A antibody Anti-RNF1 antibody |
Information sourced from Uniprot.org