| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RIN2 |
| Gene ID: | 54453 |
| Uniprot ID: | RIN2_HUMAN |
| Immunogen Region: | 596-895 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 596-895 of human RIN2 (NP_061866.1). |
| Immunogen Sequence: | HKCILKPLKGHVEAMLKDFH MADGSWKQLKENLQLVRQRN PQELGVFAPTPDFVDVEKIK VKFMTMQKMYSPEKKVMLLL RVCKLIYTVMENNSGRMYGA DDFLPVLTYVIAQCDMLELD TEIEYMMELLDPSLLHGEGG YYLTSAYGALSLIKNFQEEQ AARLLSSETRDTLRQWHKRR TTNRTIPSVDDFQNYLRVAF QEVNSGCTGKTLLVRPYITT EDVCQICAEKFKVGDPEEY |
| Tissue Specificity | Widely expressed. Expressed in heart, kidney, lung placenta. Expressed at low level in skeletal muscle, spleen and peripheral blood. |
| Function | Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. |
| Protein Name | Ras And Rab Interactor 2Ras Association Domain Family 4Ras Inhibitor Jc265Ras Interaction/Interference Protein 2 |
| Database Links | Reactome: R-HSA-8876198 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ras And Rab Interactor 2 antibodyAnti-Ras Association Domain Family 4 antibodyAnti-Ras Inhibitor Jc265 antibodyAnti-Ras Interaction/Interference Protein 2 antibodyAnti-RIN2 antibodyAnti-RASSF4 antibody |
Information sourced from Uniprot.org