Anti-Ribonuclease 7 antibody [3C2] (STJA0002899)

Anti-Ribonuclease 7 antibody [3C2] (STJA0002899)

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STJA0002899
£438.50 - £2,502.50
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Host: Mouse
Applications: ELISA/WB/IF/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Ribonuclease 7 is suitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry research applications.
Clonality : Monoclonal
Clone ID : 3C2
Conjugation: Unconjugated
Isotype: IgG1
Formulation: PBS pH 7.4, with 0.1 % sodium azide
Purification: Protein G purification
Dilution Range: ELISA 0.05 to 0.1 µg/ml; WB 0.5 to 1 µg/ml; IF 2 to 20 µg/ml; IHC 5 to 20 µg/mlMonoclonal antibody optimal dilution has to be established practically for each antigen and assay format
Storage Instruction: Store at-20 °C to-70 °C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles as product degradation may result
Gene Symbol: RNASE7
Gene ID: 84659
Uniprot ID: RNAS7_HUMAN
Specificity: Human Ribonuclease 7
Immunogen: Recombinant human RNase 7 protein produced by CHO-based proprietary suspension cell line. Human Ribonuclease 7
Tissue Specificity Expressed in collecting ducts in kidney, and in apical uroepithelium in bladder (at protein level). Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut. Expressed in liver, kidney, skeletal muscle and heart.
Function Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms including uropathogenic E.coli (UPEC), and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. Causes loss of bacterial membrane integrity. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity.
Protein Name Ribonuclease 7
Rnase 7
Skin-Derived Antimicrobial Protein 2
Sap-2
Database Links Reactome: R-HSA-6803157
Cellular Localisation Secreted
Detected In Urine
Alternative Antibody Names Anti-Ribonuclease 7 antibody
Anti-Rnase 7 antibody
Anti-Skin-Derived Antimicrobial Protein 2 antibody
Anti-Sap-2 antibody
Anti-RNASE7 antibody
Anti-UNQ2516 antibody
Anti-PRO6006 antibody

Information sourced from Uniprot.org

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