| Tissue Specificity | Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. Acetylation on Lys-92 decreases sensitivity of mitochondrial transport to elevated Ca(2+) levels, increases mitochondrial transport and promotes axon growth. Deacetylated by HDAC6 which blocks mitochondrial transport and mediates axon growth inhibition. |
| Function | Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Promotes mitochondrial fission during high calcium conditions. Can hydrolyze GTP, ATP and UTP. |
| Protein Name | Mitochondrial Rho Gtpase 1Miro-1Hmiro-1Rac-Gtp-Binding Protein-Like ProteinRas Homolog Gene Family Member T1 |
| Database Links | Reactome: R-HSA-5689880Reactome: R-HSA-9013425 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Type Iv Membrane ProteinColocalizes With Mgarp And Rhot2 At The Mitochondria |
| Alternative Antibody Names | Anti-Mitochondrial Rho Gtpase 1 antibodyAnti-Miro-1 antibodyAnti-Hmiro-1 antibodyAnti-Rac-Gtp-Binding Protein-Like Protein antibodyAnti-Ras Homolog Gene Family Member T1 antibodyAnti-RHOT1 antibodyAnti-ARHT1 antibody |
Information sourced from Uniprot.org
![Immunofluorescence analysis of HeLa cells using [KD Validated] RHOT1/MIRO1 Rabbit polyclonal antibody (STJ11104873) at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/177517/369319/STJ11104873_1__63712.1713134807.jpg?c=1 "Immunofluorescence analysis of HeLa cells using [KD Validated] RHOT1/MIRO1 Rabbit polyclonal antibody (STJ11104873) at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.")
![Immunofluorescence analysis of HeLa cells using [KD Validated] RHOT1/MIRO1 Rabbit polyclonal antibody (STJ11104873) at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/177517/369319/STJ11104873_1__63712.1713134807.jpg?c=1 "Immunofluorescence analysis of HeLa cells using [KD Validated] RHOT1/MIRO1 Rabbit polyclonal antibody (STJ11104873) at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.")
![Western blot analysis of various lysates using [KD Validated] RHOT1/MIRO1 Rabbit pAb (STJ28401) at 1:1000 dilution. <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Basic Kit <br/>Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/101691/411334/STJ28401_1__58114.1744897868.jpg?c=1 "Western blot analysis of various lysates using [KD Validated] RHOT1/MIRO1 Rabbit pAb (STJ28401) at 1:1000 dilution. <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Basic Kit <br/>Exposure time: 1s.")
