| Function | GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades. The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form. May play a role in synaptic vesicle exocytosis (Probable). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling. |
| Protein Name | Regulator Of G-Protein Signaling 7Rgs7 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-6814122 |
| Cellular Localisation | CytoplasmCytosolCell MembraneMembranePeripheral Membrane ProteinCytoplasmic SideInteraction With Pkd1 Promotes Location At The Cell MembraneInteraction With Rgs7bp Promotes Location At The Cell Membrane |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 7 antibodyAnti-Rgs7 antibodyAnti-RGS7 antibody |
Information sourced from Uniprot.org
