Anti-FPR1 antibody (155-204 aa) (STJ93133)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human FPR1 at the amino acid range 155-204
General Information
| Short Description | Rabbit polyclonal anti-fMet-Leu-Phe receptor (155-204 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FPR1 |
| Gene ID | 2357 |
| Uniprot ID | FPR1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human FPR1 at the amino acid range 155-204 |
| Immunogen Region | 155-204 aa |
| Specificity | FPR1 Polyclonal Antibody detects endogenous levels of FPR1 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated.which is necessary for desensitization. |
| Function | High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release. Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis. |
| Protein Name | Fmet-Leu-Phe ReceptorFmlp ReceptorN-Formyl Peptide ReceptorFprN-Formylpeptide Chemoattractant Receptor |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-444473Reactome: R-HSA-6783783Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInternalizes In Presence Of Its LigandsFmlpTafa4 And Ctsg |
| Alternative Antibody Names | Anti-Fmet-Leu-Phe Receptor antibodyAnti-Fmlp Receptor antibodyAnti-N-Formyl Peptide Receptor antibodyAnti-Fpr antibodyAnti-N-Formylpeptide Chemoattractant Receptor antibodyAnti-FPR1 antibody |
Information sourced from Uniprot.org