Anti-RGS16 antibody (1-202) (STJ25346)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RGS16 (1-202) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RGS16 |
| Gene ID | 6004 |
| Uniprot ID | RGS16_HUMAN |
| Immunogen Region | 1-202 |
| Immunogen Sequence | MCRTLAAFPTTCLERAKEFK TRLGIFLHKSELGCDTGSTG KFEWGSKHSKENRNFSEDVL GWRESFDLLLSSKNGVAAFH AFLKTEFSEENLEFWLACEE FKKIRSATKLASRAHQIFEE FICSEAPKEVNIDHETHELT RMNLQTATATCFDAAQGKTR TLMEKDSYPRFLKSPAYRDL AAQASAASATLSSCSLDEPS HT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-202 of human RGS16 (NP_002919.3). |
Additional Info
| Tissue Specificity | Abundantly expressed in retina with lower levels of expression in most other tissues. |
| Post Translational Modifications | Palmitoylated on Cys-2 and/or Cys-12. Phosphorylated. Phosphorylation at Tyr-168 by EGFR enhances GTPase accelerating (GAP) activity toward GNAI1. |
| Function | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals. |
| Protein Name | Regulator Of G-Protein Signaling 16Rgs16A28-Rgs14pRetinal-Specific RgsRgs-RHrgs-RRetinally Abundant Regulator Of G-Protein Signaling |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-418594Reactome: R-HSA-418597 |
| Cellular Localisation | MembraneLipid-Anchor |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 16 antibodyAnti-Rgs16 antibodyAnti-A28-Rgs14p antibodyAnti-Retinal-Specific Rgs antibodyAnti-Rgs-R antibodyAnti-Hrgs-R antibodyAnti-Retinally Abundant Regulator Of G-Protein Signaling antibodyAnti-RGS16 antibodyAnti-RGSR antibody |
Information sourced from Uniprot.org