| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Mouse/Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-RGMB (Internal Region) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | Rgmb |
| Gene ID: | 68799 |
| Uniprot ID: | RGMB_MOUSE |
| Immunogen Region: | Internal Region |
| Specificity: | Specific for RGMB. |
| Immunogen: | A synthetic peptide from internal region of mature mouse Repulsive guidance molecule B (RGMB, DRAGON) conjugated to an immunogenic carrier protein was used as the antigen. |
| Post Translational Modifications | GPI-anchored. Autocatalytically cleaved at low pH.the two chains remain linked via two disulfide bonds. |
| Function | Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system. Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling. Promotes neuronal adhesion. May inhibit neurite outgrowth. |
| Protein Name | Repulsive Guidance Molecule BDrg11-Responsive Axonal Guidance And Outgrowth Of NeuriteDragon |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane Raft |
| Alternative Antibody Names | Anti-Repulsive Guidance Molecule B antibodyAnti-Drg11-Responsive Axonal Guidance And Outgrowth Of Neurite antibodyAnti-Dragon antibodyAnti-Rgmb antibody |
Information sourced from Uniprot.org