| Function | Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription. |
| Protein Name | Dna-Binding Protein Rfx6Regulatory Factor X 6Regulatory Factor X Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-210745 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dna-Binding Protein Rfx6 antibodyAnti-Regulatory Factor X 6 antibodyAnti-Regulatory Factor X Domain-Containing Protein 1 antibodyAnti-RFX6 antibodyAnti-RFXDC1 antibody |
Information sourced from Uniprot.org
