| Host: |
Rabbit |
| Applications: |
WB/ELISA/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DNA-binding protein RFX6 (264-314 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RFX6 |
| Gene ID: |
222546 |
| Uniprot ID: |
RFX6_HUMAN |
| Immunogen Region: |
264-314 aa |
| Specificity: |
This antibody detects endogenous levels of RFX6 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human RFX6 at the amino acid range 264-314 |
| Function | Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription. |
| Protein Name | Dna-Binding Protein Rfx6Regulatory Factor X 6Regulatory Factor X Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-210745 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dna-Binding Protein Rfx6 antibodyAnti-Regulatory Factor X 6 antibodyAnti-Regulatory Factor X Domain-Containing Protein 1 antibodyAnti-RFX6 antibodyAnti-RFXDC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
