Anti-RFX6 antibody (264-314 aa) (STJ195915)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human RFX6 at the amino acid range 264-314
General Information
| Short Description | Rabbit polyclonal anti-DNA-binding protein RFX6 (264-314 aa) for use in WB, ELISA and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RFX6 |
| Gene ID | 222546 |
| Uniprot ID | RFX6_HUMAN |
| Immunogen | Synthesized peptide derived from the human RFX6 at the amino acid range 264-314 |
| Immunogen Region | 264-314 aa |
| Specificity | This antibody detects endogenous levels of RFX6 at Human/Mouse |
Additional Info
| Function | Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription. |
| Protein Name | Dna-Binding Protein Rfx6Regulatory Factor X 6Regulatory Factor X Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-210745 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dna-Binding Protein Rfx6 antibodyAnti-Regulatory Factor X 6 antibodyAnti-Regulatory Factor X Domain-Containing Protein 1 antibodyAnti-RFX6 antibodyAnti-RFXDC1 antibody |
Information sourced from Uniprot.org