• Western blot analysis of lysates from SH-SY5Y cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-RFX6 antibody (264-314 aa) (STJ195915)

SKU:
STJ195915

Current Stock:
Host: Rabbit
Applications: WB/ELISA/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DNA-binding protein RFX6 (264-314 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:50-300
ELISA 2000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RFX6
Gene ID: 222546
Uniprot ID: RFX6_HUMAN
Immunogen Region: 264-314 aa
Specificity: This antibody detects endogenous levels of RFX6 at Human/Mouse
Immunogen: Synthesized peptide derived from the human RFX6 at the amino acid range 264-314
Function Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription.
Protein Name Dna-Binding Protein Rfx6
Regulatory Factor X 6
Regulatory Factor X Domain-Containing Protein 1
Database Links Reactome: R-HSA-210745
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Dna-Binding Protein Rfx6 antibody
Anti-Regulatory Factor X 6 antibody
Anti-Regulatory Factor X Domain-Containing Protein 1 antibody
Anti-RFX6 antibody
Anti-RFXDC1 antibody

Information sourced from Uniprot.org

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