Anti-RECQL5 nanobody [SAA1003] (STJN000054)

Anti-RECQL5 nanobody [SAA1003] (STJN000054)

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STJN000054
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Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Atp-Dependent Dna Helicase Q5 is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1003
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: RECQL5
Gene ID: 9400
Uniprot ID: RECQ5_HUMAN
Post Translational Modifications Phosphorylated by CDK1 at Ser-727.this phosphorylation is required for RECQL5-mediated disruption of RAD51 filaments on stalled replication forks.
Function DNA helicase that plays an important role in DNA replication, transcription and repair. Probably unwinds DNA in a 3'-5' direction (Probable). Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability. Associates also with POLR1A and enforces the stability of ribosomal DNA arrays. Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress. Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. A core helicase fragment (residues 11-609) binds preferentially to splayed duplex, looped and ssDNA.
Protein Name Atp-Dependent Dna Helicase Q5
Dna 3'-5' Helicase Recq5
Dna Helicase - Recq-Like Type 5
Recq5
Recq Protein-Like 5
Cellular Localisation Isoform Beta: Nucleus
Nucleoplasm
Nucleus
Recruited To Sites Of Dna Damage
Such As Single-Strand Breaks And Inter-Strand Cross-Links
And At Stalled Replication Forks
Re-Localizes From The Nucleolus Into The Nucleus After Replicative Stress And Significantly Associates With Wrn During S-Phase
Isoform Alpha: Cytoplasm
Isoform Gamma: Cytoplasm
Alternative Nanobody Names Anti-Atp-Dependent Dna Helicase Q5 nanobody
Anti-Dna 3'-5' Helicase Recq5 nanobody
Anti-Dna Helicase - Recq-Like Type 5 nanobody
Anti-Recq5 nanobody
Anti-Recq Protein-Like 5 nanobody
Anti-RECQL5 nanobody
Anti-RECQ5 nanobody

Information sourced from Uniprot.org

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