![Anti-Recombinant-S100A4 antibody [SR0670] (STJA0010670)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/180565/404343/STJA0010670_7__62712.1738951567.jpg?c=1 "Anti-Recombinant-S100A4 antibody [SR0670] (STJA0010670)")
![Anti-Recombinant-S100A4 antibody [SR0670] (STJA0010670)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/180565/404343/STJA0010670_7__62712.1738951567.jpg?c=1 "Anti-Recombinant-S100A4 antibody [SR0670] (STJA0010670)")
| Host: | Rabbit |
| Applications: | WB/IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-Recombinant-S100A4 is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Monoclonal |
| Clone ID : | SR0670 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.15% ProClin300, 100 Mu g/mL BSA and 50% glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB (H, M, R) 1:500-1:2000 IHC/IF (H, M, R) 1:800-1:1600 |
| Storage Instruction: | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
| Gene Symbol: | S100A4 |
| Gene ID: | 6275 |
| Uniprot ID: | S10A4_HUMAN |
| Immunogen: | Recombinant protein corresponding to Mouse S100A4 |
| Function | Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9. Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis. Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels. Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes. In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors. |
| Protein Name | Protein S100-A4 Calvasculin Metastasin Placental Calcium-Binding Protein Protein Mts1 S100 Calcium-Binding Protein A4 |
| Cellular Localisation | Secreted Nucleus Cytoplasm |
| Alternative Antibody Names | Anti-Protein S100-A4 antibody Anti-Calvasculin antibody Anti-Metastasin antibody Anti-Placental Calcium-Binding Protein antibody Anti-Protein Mts1 antibody Anti-S100 Calcium-Binding Protein A4 antibody Anti-S100A4 antibody Anti-CAPL antibody Anti-MTS1 antibody |
Information sourced from Uniprot.org