| Function | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B.reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. |
| Protein Name | E3 Ubiquitin-Protein Ligase Bre1aBre1-AHbre1Ring Finger Protein 20Ring-Type E3 Ubiquitin Transferase Bre1a |
| Database Links | Reactome: R-HSA-8866654Reactome: R-HSA-9013422 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Bre1a antibodyAnti-Bre1-A antibodyAnti-Hbre1 antibodyAnti-Ring Finger Protein 20 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Bre1a antibodyAnti-RNF20 antibodyAnti-BRE1A antibody |
Information sourced from Uniprot.org
